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Journal: Scientific Reports
Article Title: Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma
doi: 10.1038/s41598-025-98003-1
Figure Lengend Snippet: XN and HOP EX affect HNSCC cell viability: ( A ) Xanthohumol chemical structure. ( B ) Viability assay measured by MTT (concentration range 0–25 µM XN, 0–1% HOP EX) at 48 h post-treatment. ( C ) Apoptosis analysis by Annexin V/PI assay 48 h post-treatment with IC50 (original plot Fig. C) ( D ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 and CAL-33. ( E ) Western blot results and quantification of BAX/BCL2 ratio in XN, Cisplatin, and combination treatment compared to the control. ( F ) Synergyfinder + analysis shows significant synergism in combinations of XN + Cisplatin in UMSCC-103 cis-R. ( G ) XN sensitivity (MTT assay) of UMSCC-103 cis-R cells.
Article Snippet:
Techniques: Viability Assay, Concentration Assay, Western Blot, Control, MTT Assay